
CASE DISCUSSION
Clinical Approach : Megaloblastic anemia in Children
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Case Description
Megaloblastic anemia in children is characterized by abnormally large red blood cells (megaloblasts) and is primarily caused by deficiencies in vitamin B12 or folate. A clinical approach to megaloblastic anemia in children begins with a thorough medical history and physical examination to identify...
Case Summary
- Megaloblastic anemia is characterized by large red blood cells (macro-ovalocytes) in peripheral blood smears with immature erythroid cells, and megaloblasts in the bone marrow. It arises from asynchronous maturation of the nucleus and cytoplasm in blood cell precursors due to impaired DNA synthesis. While often caused by vitamin B12 or folate deficiency, rare causes include thymidine deficiency, inborn errors of metabolism, or drug-induced issues.
Speaker Profile

Dr. Bharat Parmar
Professor And Head of Pediatrics at Zydus Medical College, Civil HospitalDr. Bharat Parmar is a distinguished pediatrician and academician with extensive expertise in child healthcare, pediatric education, and clinical pediatrics. He serves as the Professor and Head of the Department of Pediatrics at Zydus Medical College and Civil Hospital. Dr. Parmar is known for his contributions to pediatric care, medical teaching, and advancing evidence-based practices in child health and neonatal care.
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