Pharmacological Therapy For Osteoarthritis

Osteoarthritis, the most common form of arthritis, is a degenerative joint disorder characterized by the gradual deterioration of joint cartilage and the underlying bone. It often affects weight-bearing joints such as the knees, hips, and hands, leading to pain, stiffness, and reduced joint...

• Osteoarthritis (OA) affects a significant portion of the population, particularly those over 60, with prevalence rates varying between countries. While surgery remains a primary treatment option, patient acceptance is often limited due to mobility and mortality concerns associated with knee replacement. Understanding the pathobiology of OA, which involves a combination of degeneration, inflammation, and cytokine activity leading to cartilage destruction, is crucial for developing effective pharmacological interventions.