Screening and Prevention of Colorectal Cancer

Colorectal cancer remains a critical concern in clinical practice, ranking as the third most diagnosed malignancy and the second leading cause of cancer-related mortality worldwide. Its development typically follows a well-characterized adenoma-carcinoma sequence that spans 10 to 15 years,...

• Colorectal cancer represents a significant global health burden, currently standing as the third most diagnosed malignancy and the second leading cause of cancer-related mortality worldwide. The disease frequently progresses through a well-documented adenoma-carcinoma sequence, a process that typically spans 10 to 15 years, offering a critical window for intervention. While incidence rates have stabilized or declined in many high-income regions due to robust screening, there is a concerning rise in incidence within low- and middle-income countries, particularly across Africa, where presentation often occurs at a younger age.